Search results for " Colorectal surgery"

showing 10 items of 12 documents

Intraperitoneal drain placement and outcomes after elective colorectal surgery: International matched, prospective, cohort study

2022

Abstract Background Many surgeons routinely place intraperitoneal drains after elective colorectal surgery. However, enhanced recovery after surgery guidelines recommend against their routine use owing to a lack of clear clinical benefit. This study aimed to describe international variation in intraperitoneal drain placement and the safety of this practice. Methods COMPASS (COMPlicAted intra-abdominal collectionS after colorectal Surgery) was a prospective, international, cohort study which enrolled consecutive adults undergoing elective colorectal surgery (February to March 2020). The primary outcome was the rate of intraperitoneal drain placement. Secondary outcomes included: rate and tim…

AdultElective Surgical ProcedureAdult; Aged; Cohort Studies; Drainage; Elective Surgical Procedures; Female; Humans; Postoperative Complications; Prospective Studies; Surgical Wound Infection; Colorectal Surgerydrain; intrabdominaldrainAdult Aged Cohort Studies Colorectal Surgery Drainage Elective Surgical Procedures Female Humans Postoperative Complications Prospective Studies Surgical Wound InfectionSettore MED/18Cohort StudiesSettore MED/18 - Chirurgia GeneraleProspective StudiePostoperative ComplicationsElective Surgical ProceduresintrabdominalDrainageHumansSurgical Wound InfectionSurgeryFemalePostoperative ComplicationProspective StudiesCohort Studiedrain intrabdominalColorectal SurgeryHumanAged
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Evaluation and management of hemorrhoids: Italian society of colorectal surgery (SICCR) consensus statement

2015

Hemorrhoids are one of the most common medical and surgical diseases and the main reason for a visit to a coloproctologist. This consensus statement was drawn up by the Italian society of colorectal surgery in order to provide practice parameters for an accurate assessment of the disease and consequent appropriate treatment. The authors made a careful search in the main databases (MEDLINE, PubMed, Embase and Cochrane), and all results were classified on the basis of the grade of recommendation (A-C) of the American College of Chest Physicians.

Dietary FiberMaleHemorrhoidectomymedicine.medical_specialtyStatement (logic)Infrared Raysmedicine.medical_treatmentSettore MED/18 - CHIRURGIA GENERALEMEDLINEAnal CanalDiseaseHemorrhoidsHemorrhoidsPregnancySclerotherapymedicineSclerotherapyHumansDisease management (health)Medicine Chinese TraditionalLigationDigestive System Surgical ProceduresHemorrhoidectomy; Hemorrhoids; Anal Canal; Colorectal Surgery; Diet; Dietary Fiber; Digestive System Surgical Procedures; Female; Hemorrhoidectomy; Hemorrhoids; Humans; Infrared Rays; Italy; Laser Coagulation; Ligation; Male; Medicine Chinese Traditional; Pregnancy; Pregnancy Complications; Sclerotherapy; Disease Management; Gastroenterology; Surgery; Medicine (all)Laser Coagulationbusiness.industryGeneral surgeryMedicine (all)GastroenterologyDisease ManagementDigestive System Surgical ProcedureInfrared Raymedicine.diseaseColorectal surgeryPregnancy ComplicationSurgeryDietPregnancy ComplicationsItalyFemaleSurgerybusinessHemorrhoidColorectal SurgeryAbdominal surgeryHuman
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IMPROVEMENT IN REDOX HOMEOSTASIS AFTER CYTOREDUCTIVE SURGERY IN COLORECTAL ADENOCARCINOMA

2021

Colorectal cancer (CRC) as one the most common cancer type is associated with oxidative stress. Surgery is the only curative modality for early-stage CRC. The aim of this study was to evaluate the oxidative damage biomarkers as well as enzymatic and nonenzymatic antioxidants in patients with CRC before and after tumor resection and in healthy controls. 60 patients with stage I/II colorectal adenocarcinoma and 43 healthy controls were recruited in this study. We measured plasma levels of oxidative damage biomarkers, including advanced oxidation protein products (AOPP), advanced glycation end products (AGEs), malondialdehyde (MDA), and oxidized low-density lipoprotein (ox-LDL) at baseline and…

Glycation End Products AdvancedMale0301 basic medicineAgingAntioxidantColorectal cancermedicine.medical_treatmentmedicine.disease_causeBiochemistryGastroenterologychemistry.chemical_compoundPostoperative Complications0302 clinical medicineMalondialdehydeHomeostasischemistry.chemical_classificationbiologyGlutathione peroxidaseCytoreduction Surgical ProceduresGeneral MedicineMiddle AgedCatalaseMalondialdehydecolorectal cancer colorectal surgery cytoreductive surgery redox homeostasisLipoproteins LDLCatalase030220 oncology & carcinogenesisFemaleColorectal NeoplasmsResearch ArticleAdultmedicine.medical_specialtyArticle SubjectAdenocarcinomaSuperoxide dismutase03 medical and health sciencesInternal medicinemedicineHumansAgedGlutathione PeroxidaseQH573-671business.industryCell Biologymedicine.diseaseOxidative Stress030104 developmental biologychemistrybiology.proteinCytologybusinessOxidative stressLipoprotein
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Association of mechanical bowel preparation with oral antibiotics and anastomotic leak following left sided colorectal resection: an international, m…

2018

INTRODUCTION: The optimal bowel preparation strategy to minimise the risk of anastomotic leak is yet to be determined. This study aimed to determine whether oral antibiotics combined with mechanical bowel preparation (MBP+Abx) was associated with a reduced risk of anastomotic leak when compared to mechanical bowel preparation alone (MBP) or no bowel preparation (NBP).METHODS: A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 Left Sided Colorectal Resection audit was performed. Patients undergoing elective left sided colonic or rectal resection with primary anastomosis between 1 January 2017 and 15 March 2017 by any operative approach were included. The primary out…

Laparoscopic surgeryMaleLeakmedicine.medical_specialtyCathartics/administration & dosagemedicine.drug_classmedicine.medical_treatmentAntibioticsanastomotic leakanastomotic leak; bowel preparation; colonic cancer; Colorectal surgery; laparoscopic surgery; Gastroenterology030230 surgeryAnastomosisPreoperative Care/methodsNO03 medical and health sciences0302 clinical medicineColorectal surgeryAnti-Bacterial Agents/administration & dosagePreoperative CareMedicineHumansrisk factorsProspective StudiesMulti centreProspective cohort studyColectomyAgedta3126Medical Auditbusiness.industryCatharticsdigestive oral and skin physiologyGastroenterologycolonic cancerMiddle Agedlaparoscopic surgeryColorectal surgerydigestive system diseasesSurgeryAnti-Bacterial Agents030220 oncology & carcinogenesisBowel preparationbowel preparationDrug Therapy CombinationFemaleColectomy/adverse effectsbusinessAnastomotic Leak/etiology
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Pelvic exenterations for primary rectal cancer: analysis from a 10-year national prospective database

2018

Aim: to identify short-term and oncologic outcomes of pelvic exenterations (PE) for locally advanced primary rectal cancer (LAPRC) in patients included in a national prospective database. Methods: few studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Española de Cirujanos (AEC)]. Primary endpoints included procedure-associated complications, 5-year local recurrence (LR), disease-free survival (DFS) and overall survival (OS). A propensity-matched comparison with patients who underwent non-exenterative surgery for low rectal canc…

MaleColorectal cancerEpidemiologymedicine.medical_treatment030230 surgerycomputer.software_genre0302 clinical medicinePostoperative ComplicationsRetrospective StudieMedicineProspective StudiesOutcomeDatabaseGastroenterologyGeneral MedicineMiddle AgedColorectal surgeryTreatment OutcomeEfectes secundaris dels medicaments030220 oncology & carcinogenesisFemaleHumanAdvanced rectal cancermedicine.medical_specialtyRisk AssessmentDisease-Free SurvivalPelvis03 medical and health sciencesColorectal surgeryCàncer colorectalAdvanced rectal cancer Colorectal surgery Complication Outcome Pelvic exenterationRetrospective Cohort StudyHumansPerioperative PeriodEpidemiologiaAgedNeoplasm StagingRetrospective StudiesRectal NeoplasmPelvic exenterationbusiness.industryRectal NeoplasmsRectummedicine.diseaseColorectal cancerPelvic Exenterationbody regionsProspective StudieQuality of LifeDrug side effectsPostoperative ComplicationPelvic exenterationNeoplasm Recurrence LocalbusinessComplicationComplicationcomputer
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Specific TP53 and/or Ki-ras mutations as independent predictors of clinical outcome in sporadic colorectal adenocarcinomas: results of a 5-year Grupp…

2005

BACKGROUND: Although Ki-ras and TP53 mutations have probably been the genetic abnormalities most exhaustively implicated and studied in colorectal cancer (CRC) progression, their significance in terms of disease relapse and overall survival has not yet clearly been established. PATIENTS AND METHODS: A prospective study was carried out on paired tumor and normal colon tissue samples from a consecutive series of 160 previously-untreated patients, undergoing resective surgery for primary operable sporadic CRC. Mutations within the TP53 (exons 5-8) and Ki-ras (exon 2) genes were detected by PCR-SSCP analyses following sequencing. RESULTS: Mutation analyses of exons 5 to 8 of the TP53 gene showe…

MaleOncologyMultivariate analysisColorectal cancerpolymerase chain reactionmedicine.medical_treatmentLeucovorinColorectal Neoplasmmedicine.disease_causeBioinformaticsExonAntineoplastic Combined Chemotherapy ProtocolsProspective Studiesexongene mutationmultivariate analysiProspective cohort studysingle strand conformation polymorphism MeSH: Adenocarcinomaprotein p53 EMTREE medical terms: adultProto-Oncogene ProteinMutationarticleprotein domainclinical trialHematologyMiddle AgedagedItalypriority journalOncologyChemotherapy AdjuvantLymphatic MetastasisDisease ProgressionFemaleFluorouracilColorectal Neoplasmscancer tissueprognosiprospective studyHumansamplingmedicine.medical_specialtyfolinic acidgene sequenceAdenocarcinomarectum carcinomaProto-Oncogene Proteins p21(ras)outcomes researchProto-Oncogene ProteinsInternal medicinemedicineHumanscontrolled studyneoplasmsGeneNeoplasm StagingChemotherapyEMTREE drug terms: fluorouracillevamisoleAntineoplastic Combined Chemotherapy Protocolcontrolled clinical trialbusiness.industryfluorouracil; folinic acid; K ras protein; levamisole; protein p53 adult; aged; article; cancer tissue; clinical trial; codon; colon adenocarcinoma; colorectal surgery; controlled clinical trial; controlled study; exon; gene mutation; gene sequence; human; human cell; human tissue; Italy; major clinical study; male; multivariate analysis; oncology; outcomes research; polymerase chain reaction; prediction; priority journal; prognosis; prospective study; protein domain; rectum carcinoma; sampling; sequence analysis; single strand conformation polymorphism Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy Adjuvant; Colorectal Neoplasms; Disease Progression; Female; Fluorouracil; Humans; Leucovorin; Levamisole; Lymphatic Metastasis; Male; Middle Aged; Multivariate Analysis; Mutation; Neoplasm Staging; Prospective Studies; Proto-Oncogene Proteins; ras Proteins; Tumor Suppressor Protein p53 [EMTREE drug terms]human cellLymphatic Metastasipredictionras Proteinmedicine.diseasemajor clinical studyhuman tissueProto-Oncogene Proteins p21(ras)K ras proteinProspective Studiecolon adenocarcinomaMultivariate AnalysisMutationras Proteinscolorectal surgerysequence analysicodonTumor Suppressor Protein p53businessAnnals of Oncology
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Risk factors for postoperative delirium after colorectal surgery for carcinoma

2011

Background and aim: Data regarding the incidence and risk factors for postoperative delirium (PD) after gastrointestinal surgery are heterogeneous because they include both benign and malignant disease. The aim of this study was to investigate the incidence and risk factors for PD in 100 consecutive patients over 65 years who underwent colorectal surgery for carcinoma. Methods: Pre-operative cognitive function was assessed using the Mini Mental State Examination. The onset of PD was diagnosed by the Confusion Assessment Methods administered to the patients every 12 h starting from the first postoperative day to discharge. The severity of PD was also evaluated with the Delirium Rating Scale.…

Malemedicine.medical_specialtyAlcohol abuseColorectal NeoplasmAcute confusionPostoperative ComplicationsElderlyRisk FactorsColorectal surgeryInternal medicinemedicineCarcinomaHumansProspective StudiesProspective cohort studyCancerAgedUnivariate analysisMini–Mental State Examinationmedicine.diagnostic_testbusiness.industryOncology (nursing)IncidenceRisk Factorpostoperative delirium Colorectal surgery Elderly Acute confusion CancerCarcinomaPostoperative deliriumDeliriumpostoperative delirium colorectal surgeryGeneral Medicinemedicine.diseaseColorectal surgeryProspective StudieSettore MED/18 - Chirurgia GeneraleAnesthesiaDeliriumFemalePostoperative Complicationmedicine.symptomColorectal NeoplasmsbusinessComplicationMental Status ScheduleHuman
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Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery

2019

Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery.A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a c…

Malerenal failureTime Factorsmedicine.medical_treatmentAdult; Aged; Anti-Inflammatory Agents Non-Steroidal; Elective Surgical Procedures; Female; Humans; Ileus; Kaplan-Meier Estimate; Male; Middle Aged; Patient Safety; Postoperative Care; Postoperative Complications; Proportional Hazards Models; Prospective Studies; Recovery of Function; Time Factors; Treatment Outcome; Colectomy; ProctectomyAnti-Inflammatory Agentscolorectal surgery; ileus; non-steroidal anti-inflammatory drugs; NSAIDSKaplan-Meier Estimate030230 surgeryTumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]0302 clinical medicinePostoperative ComplicationsProspective StudiesProspective cohort studyColectomyColorectalColectomyRISKProctectomyHazard ratioAnti-Inflammatory Agents Non-SteroidalAcute kidney injuryMiddle AgedColorectal surgeryNSAIDTreatment OutcomeElective Surgical Procedures030220 oncology & carcinogenesisFemalePatient SafetyNon-SteroidalCohort studyAdultcolorectal Surgery ileus non-steroidal anti-inflammatory drugsmedicine.medical_specialtyIleusNon‐steroidal anti‐inflammatory drugs. NSAIDs. Postoperative ileus. Colorectal surgery.ACUTE KIDNEY INJURYanti-inflammatory agents03 medical and health sciencesIleusInternal medicinemedicineHumansAdverse effectAgedProportional Hazards Modelsnon-steroidal anti-inflammatory drugs - ileus - colorectal surgeryPostoperative Carebusiness.industryRecovery of Functionmedicine.diseaseSettore MED/18 - Chirurgia Generalecolorectal cancer.Surgerycolorectal surgerybusiness
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Emergency Colorectal Surgery Checklist and Technical Considerations

2019

A surgical checklist is a step-by-step control procedure carried on for checking through the most delicate phases of the perioperative period, in order to increase surgical patient’s safety and avoid preventable complications. The checklist implementation within operating rooms have proved to be effective in reducing morbidity and mortality rates significantly, without being costly and lengthy. These results have been confirmed also in emergency surgery, which represents in itself a cause of higher risks for patients. Thus, the checklist use has rapidly spread out all over the world. The mechanism responsible for the improvement of surgical outcomes is not completely clear, partly due to am…

Surgical teammedicine.medical_specialtySurgical Safety Checklistbusiness.industryEmergency colorectal surgeryPatient positioningPerioperativemedicine.diseaseColorectal surgeryChecklistSettore MED/18 - Chirurgia GeneraleEmergency surgerymedicineMedical emergencySurgical checklistbusinessSurgical patients
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What are the risk factors of failure of enhanced recovery after right colectomy? Results of a prospective study on 140 consecutive cases

2020

Purpose Nausea and vomiting is the main cause of failure of enhanced recovery protocol (ERP) after right hemicolectomy. Methods From January 2013 to January 2018, all patients undergoing right hemicolectomy were prospectively included. Patients undergoing emergency surgery, additional complex procedure or temporary stoma, nasogastric tube (NGT) maintenance, or abdominal drainage were excluded. Failure of ERP was defined as nausea/vomiting precluding oral feeding after POD3 and/or the occurrence of postoperative ileus requiring NGT and/or length of stay (LOS) ≥ 8 days except for patients awaiting admission in rehabilitation unit. Risk factors of failure of ERP were identified using univariat…

medicine.medical_specialtyAnemiaNauseaRight colectomy enhanced recovery ERAS perioperative care postoperative outcome colorectal surgery03 medical and health sciences0302 clinical medicineIleusPostoperative ComplicationsRisk FactorsmedicineHumansProspective StudiesProspective cohort studyContraindicationColectomybusiness.industryMortality rateGastroenterologyLength of Staymedicine.diseaseColorectal surgerySurgery030220 oncology & carcinogenesisRight ColectomyVomiting030211 gastroenterology & hepatologymedicine.symptombusiness
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